Emergency crews responded after two explosions were heard and a billowing plume of smoke could be seen rising from a six-story commercial building in a densely populated area close to the city's financial district.
Deepak Chagger, a spokesperson with Toronto Fire Services, said the fire broke out in an area of the roof where construction work was taking place.
He said three propane cylinders had ruptured as a result of the fire.
Fire crews extinguished the fire and there were no injuries reported, Chagger said.
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